Oral Escherichia coli Colonization Factor Antigen I (CFA/I) Fimbriae Ameliorate Arthritis via IL-35, not IL-27

A Salmonella therapeutic expressing enterotoxigenic E. coli colonization factor antigen I (CFA/I) fimbriae protects against collagen-induced arthritis (CIA) by eliciting two regulatory T cell (Treg) subsets: TGF-β-producing Foxp3(−)CD39(+)CD4(+) and IL-10-producing Foxp3(+)CD39(+)CD4(+) T cells. How...

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Bibliographic Details
Main Authors: Kochetkova, Irina, Thornburg, Theresa, Callis, Gayle, Holderness, Kathryn, Maddaloni, Massimo, Pascual, David W.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903302/
https://ncbi.nlm.nih.gov/pubmed/24337375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302018
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