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IL-35 Stimulation of CD39(+) Regulatory T Cells Confers Protection against Collagen II-Induced Arthritis via the Production of IL-10
IL-35 is produced by regulatory T cells, and this novel cytokine can downregulate Th17 cell development and inhibit autoimmune inflammation. In this work, an rIL-35, as a single-chain fusion between murine IL-12p35 and EBV-induced gene 3, was expressed in yeast. This rIL-35 inhibited OVA-specific ce...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145775/ https://ncbi.nlm.nih.gov/pubmed/20483737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902739 |
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