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Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple anomalous dispersion

We report here the solid phase synthesis of RNA and DNA oligonucleotides containing the 2′-selenium functionality for X-ray crystallography using multiwavelength anomalous dispersion. We have synthesized the novel 2′-methylseleno cytidine phosphoramidite and improved the accessibility of the 2′-meth...

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Bibliografske podrobnosti
Main Authors: Carrasco, Nicolas, Buzin, Yuri, Tyson, Elizabeth, Halpert, Elizer, Huang, Zhen
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC390325/
https://ncbi.nlm.nih.gov/pubmed/15007109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh325
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