Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis

Pituitary tumor transforming gene 1 (Pttg1) encodes the mammalian securin, which is an inhibitor of separase (a protease required for the separation of sister chromatids in mitosis and meiosis). PTTG1 is overexpressed in a number of human cancers and has been suggested to be an oncogene. However, we...

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Detaylı Bibliyografya
Asıl Yazarlar: Hatcher, Rashieda J., Dong, Jie, Liu, Shuang, Bian, Guangxing, Contreras, Alejandro, Wang, Tao, Hilsenbeck, Susan G., Li, Yi, Zhang, Pumin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903200/
https://ncbi.nlm.nih.gov/pubmed/24395789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318124111
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