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Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis
Pituitary tumor transforming gene 1 (Pttg1) encodes the mammalian securin, which is an inhibitor of separase (a protease required for the separation of sister chromatids in mitosis and meiosis). PTTG1 is overexpressed in a number of human cancers and has been suggested to be an oncogene. However, we...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3903200/ https://ncbi.nlm.nih.gov/pubmed/24395789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318124111 |
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