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5′-Untranslated regions with multiple upstream AUG codons can support low-level translation via leaky scanning and reinitiation

Upstream AUGs (uAUGs) and upstream open reading frames (uORFs) are common features of mRNAs that encode regulatory proteins and have been shown to profoundly influence translation of the main ORF. In this study, we employed a series of artificial 5′-untranslated regions (5′-UTRs) containing one or m...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Wang, Xue-Qing, Rothnagel, Joseph A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2004
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Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390293/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14990743/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh305
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