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Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity
SMARCAL1 promotes the repair and restart of damaged replication forks. Either overexpression or silencing SMARCAL1 causes the accumulation of replication-associated DNA damage. SMARCAL1 is heavily phosphorylated. Here we identify multiple phosphorylation sites, including S889, which is phosphorylate...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902923/ https://ncbi.nlm.nih.gov/pubmed/24150942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt929 |
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