Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity

SMARCAL1 promotes the repair and restart of damaged replication forks. Either overexpression or silencing SMARCAL1 causes the accumulation of replication-associated DNA damage. SMARCAL1 is heavily phosphorylated. Here we identify multiple phosphorylation sites, including S889, which is phosphorylate...

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Bibliografske podrobnosti
Main Authors: Carroll, Clinton, Bansbach, Carol E., Zhao, Runxiang, Jung, Sung Yun, Qin, Jun, Cortez, David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902923/
https://ncbi.nlm.nih.gov/pubmed/24150942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt929
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