Clinical Impact of Cytochrome P450 2C19 Genotype on the Treatment of Invasive Aspergillosis under Routine Therapeutic Drug Monitoring of Voriconazole in a Korean Population

BACKGROUND: Genetic polymorphisms of cytochrome P450 enzymes, especially CYP2C19 influence voriconazole pharmacokinetics. However, the impact of CYP2C19 genetic polymorphisms on the therapeutic efficacy and toxicity of voriconazole therapy are not well established. MATERIALS AND METHODS: In this pro...

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Main Authors: Kim, Si-Hyun, Lee, Dong-Gun, Kwon, Jae-Cheol, Lee, Hyo-Jin, Cho, Sung-Yeon, Park, Chulmin, Kwon, Eun-Young, Park, Sun Hee, Choi, Su-Mi, Choi, Jung-Hyun, Yoo, Jin-Hong
Format: Artigo
Jezik:Inglês
Izdano: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902809/
https://ncbi.nlm.nih.gov/pubmed/24475354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3947/ic.2013.45.4.406
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