Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics

Recently the structure of BAY58-2667 bound to the Nostoc sp. H-NOX domain was published. Based on this structural information, we designed BAY58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crysta...

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Bibliografiske detaljer
Main Authors: Rekowski, Margarete von Wantoch, Kumar, Vijay, Zhou, Zongmin, Moschner, Johann, Marazioti, Antonia, Bantzi, Marina, Spyroulias, Georgios A., van den Akker, Focco, Giannis, Athanassios, Papapetropoulos, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902542/
https://ncbi.nlm.nih.gov/pubmed/24090476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400539d
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