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Recovering a Representative Conformational Ensemble from Underdetermined Macromolecular Structural Data

Structural analysis of proteins and nucleic acids is complicated by their inherent flexibility, conferred, for example, by linkers between their contiguous domains. Therefore, the macromolecule needs to be represented by an ensemble of conformations instead of a single conformation. Determining this...

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Detalhes bibliográficos
Main Authors: Berlin, Konstantin, Castañeda, Carlos A., Schneidman-Duhovny, Dina, Sali, Andrej, Nava-Tudela, Alfredo, Fushman, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902174/
https://ncbi.nlm.nih.gov/pubmed/24093873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4083717
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