Image-Based Noninvasive Evaluation of Colorectal Mucosal Injury in Sheep Following Topical Application of Microbicides

BACKGROUND: Successful development of topical rectal microbicides requires preclinical evaluation in suitable large animal models. Our previous studies have demonstrated the benefits of high resolution optical coherence tomography (OCT) to visualize subclinical microbicide toxicity in the sheep vagi...

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Main Authors: Vincent, Kathleen L., Vargas, Gracie, Bourne, Nigel, Turner, Valerie, Saada, Jamal I., Lee, Gabe, Sbrana, Elena, Motamedi, Massoud
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901848/
https://ncbi.nlm.nih.gov/pubmed/24113407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/OLQ.0000000000000039
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