Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states

Synthetic kappa-opioid receptor (KOR) agonists induce dysphoric and pro-depressive effects, and variations in the KOR (OPRK1) and prodynorphin (PDYN) genes have been shown to be associated with alcohol dependence. We genotyped 23 single nucleotide polymorphisms (SNPs) in the PDYN and OPRK1 genes in...

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Auteurs principaux: Karpyak, Victor M., Winham, Stacey J., Preuss, Ulrich W., Zill, Peter, Cunningham, Julie M., Walker, Denise L., Lewis, Kriste A., Geske, Jennifer R., Colby, Colin L., Abulseoud, Osama A., Hall-Flavin, Daniel K., Loukianova, Larissa L., Schneekloth, Terry D., Frye, Mark A, Bazov, Igor, Heit, John A., Bakalkin, Georgy, Mrazek, David A., Biernacka, Joanna M.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901318/
https://ncbi.nlm.nih.gov/pubmed/23101464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145712001137
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