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Non-invasive In-cell Determination of Free Cytosolic [NAD(+)]/[NADH] Ratios Using Hyperpolarized Glucose Show Large Variations in Metabolic Phenotypes

Accumulating evidence suggest that the pyridine nucleotide NAD has far wider biological functions than its classical role in energy metabolism. NAD is used by hundreds of enzymes that catalyze substrate oxidation and, as such, it plays a key role in various biological processes such as aging, cell d...

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Detalhes bibliográficos
Main Authors: Christensen, Caspar Elo, Karlsson, Magnus, Winther, Jakob R., Jensen, Pernille Rose, Lerche, Mathilde H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900977/
https://ncbi.nlm.nih.gov/pubmed/24302737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498626
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