Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production

MAPK activity is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ in expression, substrate specificity, and subcellular localization. Here, we investigated the function of Dusp16/MKP-7 in the innate immune system. The Dusp16 isoforms A1 and B1 were indu...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Niedzielska, Magdalena, Bodendorfer, Barbara, Münch, Sandra, Eichner, Alexander, Derigs, Marcus, da Costa, Olivia, Schweizer, Astrid, Neff, Frauke, Nitschke, Lars, Sparwasser, Tim, Keyse, Stephen M., Lang, Roland
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2014
विषय:
Signal Transduction
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900958/
https://ncbi.nlm.nih.gov/pubmed/24311790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535245
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