Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production

MAPK activity is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ in expression, substrate specificity, and subcellular localization. Here, we investigated the function of Dusp16/MKP-7 in the innate immune system. The Dusp16 isoforms A1 and B1 were indu...

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Autores principales: Niedzielska, Magdalena, Bodendorfer, Barbara, Münch, Sandra, Eichner, Alexander, Derigs, Marcus, da Costa, Olivia, Schweizer, Astrid, Neff, Frauke, Nitschke, Lars, Sparwasser, Tim, Keyse, Stephen M., Lang, Roland
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900958/
https://ncbi.nlm.nih.gov/pubmed/24311790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535245
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