Gene Trap Mice Reveal an Essential Function of Dual Specificity Phosphatase Dusp16/MKP-7 in Perinatal Survival and Regulation of Toll-like Receptor (TLR)-induced Cytokine Production

MAPK activity is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ in expression, substrate specificity, and subcellular localization. Here, we investigated the function of Dusp16/MKP-7 in the innate immune system. The Dusp16 isoforms A1 and B1 were indu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Niedzielska, Magdalena, Bodendorfer, Barbara, Münch, Sandra, Eichner, Alexander, Derigs, Marcus, da Costa, Olivia, Schweizer, Astrid, Neff, Frauke, Nitschke, Lars, Sparwasser, Tim, Keyse, Stephen M., Lang, Roland
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900958/
https://ncbi.nlm.nih.gov/pubmed/24311790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535245
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg