Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts.

The globin chain synthetic pattern and the extent of DNA methylation within embryonic, fetal, and adult beta-like globin gene domains were evaluated in greater than or equal to 90% purified human erythroblasts from yolk sacs and fetal livers in the 6- to 12-wk gestational period as well as from adul...

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Main Authors: Mavilio, F, Giampaolo, A, Carè, A, Migliaccio, G, Calandrini, M, Russo, G, Pagliardi, G L, Mastroberardino, G, Marinucci, M, Peschle, C
Format: Artigo
Language:Inglês
Published: 1983
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC390095/
https://ncbi.nlm.nih.gov/pubmed/6316333
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