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The Replication Initiation Protein Sld2 Regulates Helicase Assembly

Assembly of the Cdc45-Mcm2-7-GINS (CMG) replicative helicase complex must be regulated to ensure that DNA unwinding is coupled with DNA synthesis. Sld2 is required for the initiation of DNA replication in budding yeast. We identified a mutant of Sld2, Sld2-m1,4, that is specifically defective in Mcm...

詳細記述

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書誌詳細
主要な著者: Bruck, Irina, Kaplan, Daniel L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900945/
https://ncbi.nlm.nih.gov/pubmed/24307213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532085
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