Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels

BACKGROUND: Wilms tumor 1 (WT1) is over-expressed in numerous cancers with respect to normal cells, and has either a tumor suppressor or oncogenic role depending on cellular context. This gene is associated with numerous alternatively spliced transcripts, which initiate from two different unique fir...

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Hauptverfasser: Guillaumet-Adkins, Amy, Richter, Julia, Odero, Maria D, Sandoval, Juan, Agirre, Xabi, Catala, Albert, Esteller, Manel, Prósper, Felipe, Calasanz, María José, Buño, Ismael, Kwon, Mi, Court, Franck, Siebert, Reiner, Monk, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900738/
https://ncbi.nlm.nih.gov/pubmed/24405639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-4
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