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Ketoconazole Inhibits the Cellular Uptake of Anandamide via Inhibition of FAAH at Pharmacologically Relevant Concentrations

BACKGROUND: The antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have investigated whether ketoconazole affects t...

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Autors principals: Björklund, Emmelie, Larsson, Therése N. L., Jacobsson, Stig O. P., Fowler, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900727/
https://ncbi.nlm.nih.gov/pubmed/24466356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087542
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