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Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake

BACKGROUND AND PURPOSE: Genistein, a tyrosine kinase inhibitor used to block caveolae dependent endocytosis, reduces the cellular uptake of anandamide in RBL2H3 basophilic leukaemia cells. However, genistein is also a competitive inhibitor of fatty acid amide hydrolase, the enzyme responsible for an...

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Detalhes bibliográficos
Main Authors: Thors, L, Eriksson, J, Fowler, C J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190009/
https://ncbi.nlm.nih.gov/pubmed/17676056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707401
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