A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

Impaired angiogenesis in ischemic tissue is a hallmark of diabetes. Thioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed in diabetes. As TXNIP modulates the activity of the key angiogenic cytokine vascular endothelial growth factor (VEGF), we hypothe...

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Detalhes bibliográficos
Main Authors: Dunn, Louise L., Simpson, Philippa J.L., Prosser, Hamish C., Lecce, Laura, Yuen, Gloria S.C., Buckle, Andrew, Sieveking, Daniel P., Vanags, Laura Z., Lim, Patrick R., Chow, Renee W.Y., Lam, Yuen Ting, Clayton, Zoe, Bao, Shisan, Davies, Michael J., Stadler, Nadina, Celermajer, David S., Stocker, Roland, Bursill, Christina A., Cooke, John P., Ng, Martin K.C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900553/
https://ncbi.nlm.nih.gov/pubmed/24198286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0417
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