A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

Impaired angiogenesis in ischemic tissue is a hallmark of diabetes. Thioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed in diabetes. As TXNIP modulates the activity of the key angiogenic cytokine vascular endothelial growth factor (VEGF), we hypothe...

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Main Authors: Dunn, Louise L., Simpson, Philippa J.L., Prosser, Hamish C., Lecce, Laura, Yuen, Gloria S.C., Buckle, Andrew, Sieveking, Daniel P., Vanags, Laura Z., Lim, Patrick R., Chow, Renee W.Y., Lam, Yuen Ting, Clayton, Zoe, Bao, Shisan, Davies, Michael J., Stadler, Nadina, Celermajer, David S., Stocker, Roland, Bursill, Christina A., Cooke, John P., Ng, Martin K.C.
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2014
主題:
Pathophysiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900553/
https://ncbi.nlm.nih.gov/pubmed/24198286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0417
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