A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

Impaired angiogenesis in ischemic tissue is a hallmark of diabetes. Thioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed in diabetes. As TXNIP modulates the activity of the key angiogenic cytokine vascular endothelial growth factor (VEGF), we hypothe...

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Bibliografski detalji
Glavni autori: Dunn, Louise L., Simpson, Philippa J.L., Prosser, Hamish C., Lecce, Laura, Yuen, Gloria S.C., Buckle, Andrew, Sieveking, Daniel P., Vanags, Laura Z., Lim, Patrick R., Chow, Renee W.Y., Lam, Yuen Ting, Clayton, Zoe, Bao, Shisan, Davies, Michael J., Stadler, Nadina, Celermajer, David S., Stocker, Roland, Bursill, Christina A., Cooke, John P., Ng, Martin K.C.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2014
Teme:
Pathophysiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900553/
https://ncbi.nlm.nih.gov/pubmed/24198286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0417
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