Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy

Podocytes are a major component of the glomerular filtration barrier, and their ability to sense insulin is essential to prevent proteinuria. Here we identify the insulin downstream effector GLUT4 as a key modulator of podocyte function in diabetic nephropathy (DN). Mice with a podocyte-specific del...

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Detalhes bibliográficos
Main Authors: Guzman, Johanna, Jauregui, Alexandra N., Merscher-Gomez, Sandra, Maiguel, Dony, Muresan, Cristina, Mitrofanova, Alla, Diez-Sampedro, Ana, Szust, Joel, Yoo, Tae-Hyun, Villarreal, Rodrigo, Pedigo, Christopher, Molano, R. Damaris, Johnson, Kevin, Kahn, Barbara, Hartleben, Bjoern, Huber, Tobias B., Saha, Jharna, Burke, George W., Abel, E. Dale, Brosius, Frank C., Fornoni, Alessia
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900538/
https://ncbi.nlm.nih.gov/pubmed/24101677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0752
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