Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques

HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24(gag) elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited respo...

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Detalhes bibliográficos
Main Authors: Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, Singh, Ashish K., Jalah, Rashmi, Broderick, Kate E., Sardesai, Niranjan Y., Le Gall, Sylvie, Mothe, Beatriz, Brander, Christian, Rolland, Morgane, Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900501/
https://ncbi.nlm.nih.gov/pubmed/24465991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086254
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