The Incidence of Liver Injury in Uyghur Patients Treated for TB in Xinjiang Uyghur Autonomous Region, China, and Its Association with Hepatic Enzyme Polymorphisms NAT2, CYP2E1, GSTM1 and GSTT1

BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing e...

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Detalhes bibliográficos
Main Authors: Xiang, Yang, Ma, Long, Wu, Weidong, Liu, Wei, Li, Yongguang, Zhu, Xia, Wang, Qian, Ma, Jinfeng, Cao, Mingqin, Yao, Xuemei, Yang, Lei, Wubuli, Atikaimu, Merle, Corinne, Milligan, Paul, Mao, Ying, Gu, Jiayi, Xin, Xiumei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900431/
https://ncbi.nlm.nih.gov/pubmed/24465778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085905
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