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An Allosteric Signaling Pathway of Human 3-Phosphoglycerate Kinase from Force Distribution Analysis

3-Phosphogycerate kinase (PGK) is a two domain enzyme, which transfers a phosphate group between its two substrates, 1,3-bisphosphoglycerate bound to the N-domain and ADP bound to the C-domain. Indispensable for the phosphoryl transfer reaction is a large conformational change from an inactive open...

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書目詳細資料
Main Authors: Palmai, Zoltan, Seifert, Christian, Gräter, Frauke, Balog, Erika
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900376/
https://ncbi.nlm.nih.gov/pubmed/24465199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003444
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