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FGF-FGFR Signaling Mediated through Glycosaminoglycans in Microtiter Plate and Cell-Based Microarray Platforms

Fibroblast growth factor (FGF) signals cell growth through its interaction with a fibroblast growth factor receptor (FGFR) and a glycosaminoglycn (GAG) co-receptor. Here we examine the signaling of five different FGFs (FGF1, FGF2, FGF6, FGF8 and FGF8b) through FGFR3c. A small library of GAG and GAG-...

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Detalhes bibliográficos
Main Authors: Sterner, Eric, Meli, Luciana, Kwon, Seok-Joon, Dordick, Jonathan S., Linhardt, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900324/
https://ncbi.nlm.nih.gov/pubmed/24289246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401284r
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