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Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists

Understanding the structural mechanism of receptor–ligand interactions for the chemokine receptor CXCR4 is essential for determining its physiological and pathological functions and for developing new therapies targeted to CXCR4. We have recently reported a structural mechanism for CXCR4 antagonism...

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Hlavní autoři: Kawatkar, Sameer P, Yan, Maocai, Gevariya, Harsukh, Lim, Mi Youn, Eisold, Steven, Zhu, Xuejun, Huang, Ziwei, An, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900290/
https://ncbi.nlm.nih.gov/pubmed/21697335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1258/ebm.2011.010345
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