Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3

BACKGROUND AND PURPOSE: The chemokine receptor CXCR3 is a GPCR found predominantly on activated T cells. CXCR3 is activated by three endogenous peptides; CXCL9, CXCL10 and CXCL11. Recently, a small-molecule agonist, VUF10661, has been reported in the literature and synthesized in our laboratory. The...

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Main Authors: Scholten, DJ, Canals, M, Wijtmans, M, de Munnik, S, Nguyen, P, Verzijl, D, de Esch, IJP, Vischer, HF, Smit, MJ, Leurs, R
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2012
Fag:
Research Papers with Commentary
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417417/
https://ncbi.nlm.nih.gov/pubmed/21883151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01648.x
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