Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma

BACKGROUND: Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is a highly effective alkylating agent which causes many types of DNA lesions, inc...

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書誌詳細
主要な著者: Xie, Jiayin, Zhang, Liang, Li, Mengxia, Du, Jia, Zhou, Liwei, Yang, Senlin, Zeng, Linli, Li, Zengpeng, Wang, Ge, Wang, Dong
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900260/
https://ncbi.nlm.nih.gov/pubmed/24400589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-11
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