Tunicamycin inhibits ganglioside biosynthesis in rat liver Golgi apparatus by blocking sugar nucleotide transport across the membrane vesicles.

The synthesis of ganglioside GM1 in intact rat liver Golgi-derived vesicles is stimulated by phosphatidylglycerol as much (about 20-fold) as by Triton X-100. The antibiotic tunicamycin inhibits strongly the synthesis, in the presence as well as in the absence of the phospholipid, but has no effect w...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Yusuf, H K, Pohlentz, G, Sandhoff, K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC389995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6417662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.23.7075
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