A frameshift mutation affecting the carboxyl terminus of the simian virus 40 large tumor antigen results in a replication- and transformation-defective virus.

We have constructed a frameshift mutation in the simian virus 40 early region using a novel method of oligonucleotide-directed mutagenesis. The mutated DNA specifies an 84,000-dalton large tumor antigen that consists of approximately equal to 75,000 daltons encoded by the wild-type reading frame and...

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Hlavní autoři: Lewis, E D, Chen, S, Kumar, A, Blanck, G, Pollack, R E, Manley, J L
Médium: Artigo
Jazyk:Inglês
Vydáno: 1983
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC389993/
https://ncbi.nlm.nih.gov/pubmed/6316342
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