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Separate enrichment analysis of pathways for up- and downregulated genes

Two strategies are often adopted for enrichment analysis of pathways: the analysis of all differentially expressed (DE) genes together or the analysis of up- and downregulated genes separately. However, few studies have examined the rationales of these enrichment analysis strategies. Using both micr...

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Bibliographic Details
Main Authors: Hong, Guini, Zhang, Wenjing, Li, Hongdong, Shen, Xiaopei, Guo, Zheng
Format: Artigo
Language:Inglês
Published: The Royal Society 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899863/
https://ncbi.nlm.nih.gov/pubmed/24352673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2013.0950
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