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Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells
The androgen receptor (AR) has a vital role in the onset and progression of prostate cancer by promoting G1-S progression, possibly by functioning as a licensing factor for DNA replication. We here report that low dose 2-methoxyestradiol (2-ME), an endogenous estrogen metabolite, induces mitotic arr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3899837/ https://ncbi.nlm.nih.gov/pubmed/23246967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.561 |
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