Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models

BACKGROUND: Fibroblast growth factor receptor (FGFR) signalling has been implicated in pancreas carcinogenesis. We investigated the effect of FGFR inhibition in pancreatic cancer in complementary cancer models derived from cell lines and patient-derived primary tumour explants. METHODS: The effects...

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Main Authors: Zhang, H, Hylander, B L, LeVea, C, Repasky, E A, Straubinger, R M, Adjei, A A, Ma, W W
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Translational Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899776/
https://ncbi.nlm.nih.gov/pubmed/24327018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.754
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