Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming

BACKGROUND: Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional environment. In a rat model, both male and femal...

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Autores principales: Ellis, Peter JI, Morris, Tiffany J, Skinner, Benjamin M, Sargent, Carole A, Vickers, Mark H, Gluckman, Peter D, Gilmour, Stewart, Affara, Nabeel A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899603/
https://ncbi.nlm.nih.gov/pubmed/24447410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-49
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