Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis.
The pores of voltage-gated ion channels are lined by protein loops that determine selectivity and conductance. The relative orientations of these "P" loops remain uncertain, as do the distances between them. Using site-directed mutagenesis, we introduced pairs of cysteines into the P loops of micro1...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8693004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7392 |
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