Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis.

The pores of voltage-gated ion channels are lined by protein loops that determine selectivity and conductance. The relative orientations of these "P" loops remain uncertain, as do the distances between them. Using site-directed mutagenesis, we introduced pairs of cysteines into the P loops of micro1...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Bénitah, J P, Tomaselli, G F, Marban, E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8693004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7392
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