Tumor Vasculature-Targeted Recombinant Mutated Human TNF-α Enhanced the Antitumor Activity of Doxorubicin by Increasing Tumor Vessel Permeability in Mouse Xenograft Models

OBJECTIVE: Increasing evidence suggests that, when used in combination, tumor necrosis factor-α (TNF-α) synergizes with traditional chemotherapeutic drugs to exert a heightened antitumor effect. The present study investigated the antitumor efficacy of recombinant mutated human TNF-α specifically tar...

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Hauptverfasser: Jiang, Changli, Niu, Junzhou, Li, Meng, Teng, Yi, Wang, Huixuan, Zhang, Yingqi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899378/
https://ncbi.nlm.nih.gov/pubmed/24466321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087036
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