Sirtuin 1 (SIRT1) Activation Mediates Sildenafil Induced Delayed Cardioprotection against Ischemia-Reperfusion Injury in Mice

BACKGROUND: It has been well documented that phosphodiesterase-5 inhibitor, sildenafil (SIL) protects against myocardial ischemia/reperfusion (I-R) injury. SIRT1 is part of the class III Sirtuin family of histone deacetylases that deacetylates proteins involved in cellular stress response including...

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Autors principals: Shalwala, Mona, Zhu, Shu-Guang, Das, Anindita, Salloum, Fadi N., Xi, Lei, Kukreja, Rakesh C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899366/
https://ncbi.nlm.nih.gov/pubmed/24466304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086977
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