Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization

Targeting early infection in mucosal sites is one of the primary goals for mucosal vaccines so as to prevent pathogen mucosal transmission and infection. The TLR5 agonist flagellin was deemed to be a mucosal adjuvant candidate for clinical usage. However, the high antigenicity of flagellin and the p...

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Detalhes bibliográficos
Main Authors: Yang, Jingyi, Zhong, Maohua, Zhang, Yan, Zhang, Ejuan, Sun, Ying, Cao, Yuan, Li, Yaoming, Zhou, Dihan, He, Benxia, Chen, Yaoqing, Yang, Yi, Yu, Jie, Yan, Huimin
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899144/
https://ncbi.nlm.nih.gov/pubmed/23377752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.23809
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