pTyr(421) Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)

Cortactin (CTTN), first identified as a major substrate of the Src tyrosine kinase, actively participates in branching F-actin assembly and in cell motility and invasion. CTTN gene is amplified and its protein is overexpressed in several types of cancer. The phosphorylated form of cortactin (pTyr(42...

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Bibliografiske detaljer
Main Authors: Radhakrishnan, Vijayababu M., Kojs, Pawel, Young, Gavin, Ramalingam, Rajalakshmy, Jagadish, Bhumasamudram, Mash, Eugene A., Martinez, Jesse D., Ghishan, Fayez K., Kiela, Pawel R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899080/
https://ncbi.nlm.nih.gov/pubmed/24465712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085796
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