Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration,...

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Main Authors: Chu, X, Korzekwa, K, Elsby, R, Fenner, K, Galetin, A, Lai, Y, Matsson, P, Moss, A, Nagar, S, Rosania, GR, Bai, JPF, Polli, JW, Sugiyama, Y, Brouwer, KLR
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898878/
https://ncbi.nlm.nih.gov/pubmed/23588320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.78
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