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Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver
Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration,...
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| Main Authors: | , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898878/ https://ncbi.nlm.nih.gov/pubmed/23588320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.78 |
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