Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration,...

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Detalhes bibliográficos
Main Authors: Chu, X, Korzekwa, K, Elsby, R, Fenner, K, Galetin, A, Lai, Y, Matsson, P, Moss, A, Nagar, S, Rosania, GR, Bai, JPF, Polli, JW, Sugiyama, Y, Brouwer, KLR
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898878/
https://ncbi.nlm.nih.gov/pubmed/23588320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.78
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