High-Resolution Replication Profiles Define the Stochastic Nature of Genome Replication Initiation and Termination

Eukaryotic genome replication is stochastic, and each cell uses a different cohort of replication origins. We demonstrate that interpreting high-resolution Saccharomyces cerevisiae genome replication data with a mathematical model allows quantification of the stochastic nature of genome replication,...

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Autores principales: Hawkins, Michelle, Retkute, Renata, Müller, Carolin A., Saner, Nazan, Tanaka, Tomoyuki U., de Moura, Alessandro P.S., Nieduszynski, Conrad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898788/
https://ncbi.nlm.nih.gov/pubmed/24210825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.014
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