siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors

BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/− female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS) characterized by early-onset of breast cancer, even though LFS involves TP5...

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Autors principals: Böhringer, M, Obermeier, K, Griner, N, Waldraff, D, Dickinson, E, Eirich, K, Schindler, D, Hagen, M, Jerry, D J, Wiesmüller, L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898496/
https://ncbi.nlm.nih.gov/pubmed/23435420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.38
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