Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients

BACKGROUND: During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter...

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Main Authors: Schilder, Louise, Nurmohamed, S Azam, ter Wee, Pieter M, Paauw, Nanne J, Girbes, Armand RJ, Beishuizen, Albertus, Beelen, Robert HJ, Groeneveld, AB Johan
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898382/
https://ncbi.nlm.nih.gov/pubmed/24438360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-15-19
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