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Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients

BACKGROUND: During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter...

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書誌詳細
主要な著者: Schilder, Louise, Nurmohamed, S Azam, ter Wee, Pieter M, Paauw, Nanne J, Girbes, Armand RJ, Beishuizen, Albertus, Beelen, Robert HJ, Groeneveld, AB Johan
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898382/
https://ncbi.nlm.nih.gov/pubmed/24438360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-15-19
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