Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

Subvisible proteinaceous particles which are present in all therapeutic protein formulations are in the focus of intense discussions between health authorities, academics and biopharmaceutical companies in the context of concerns that such particles could promote unwanted immunogenicity via anti-dru...

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Main Authors: Rombach-Riegraf, Verena, Karle, Anette C., Wolf, Babette, Sordé, Laetitia, Koepke, Stephan, Gottlieb, Sascha, Krieg, Jennifer, Djidja, Marie-Claude, Baban, Aida, Spindeldreher, Sebastian, Koulov, Atanas V., Kiessling, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897673/
https://ncbi.nlm.nih.gov/pubmed/24466023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086322
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