Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia

RATIONALE AND OBJECTIVE: Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity. In this study Arg1(fl/fl)/Tie2-Cre(tg/−) mice were developed to investigate the effect of arginase-1 related arg...

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Main Authors: Wijnands, Karolina A. P., Hoeksema, Marten A., Meesters, Dennis M., van den Akker, Nynke M. S., Molin, Daniel G. M., Briedé, Jacob J., Ghosh, Mitrajit, Köhler, S. Eleonore, van Zandvoort, Marc A. M. J., de Winther, Menno P. J., Buurman, Wim A., Lamers, Wouter H., Poeze, Martijn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897658/
https://ncbi.nlm.nih.gov/pubmed/24465919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086135
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