Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia

RATIONALE AND OBJECTIVE: Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity. In this study Arg1(fl/fl)/Tie2-Cre(tg/−) mice were developed to investigate the effect of arginase-1 related arg...

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Autors principals: Wijnands, Karolina A. P., Hoeksema, Marten A., Meesters, Dennis M., van den Akker, Nynke M. S., Molin, Daniel G. M., Briedé, Jacob J., Ghosh, Mitrajit, Köhler, S. Eleonore, van Zandvoort, Marc A. M. J., de Winther, Menno P. J., Buurman, Wim A., Lamers, Wouter H., Poeze, Martijn
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897658/
https://ncbi.nlm.nih.gov/pubmed/24465919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086135
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