Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling

SHARPIN is a key regulator of NFKB and integrin signaling. Mice lacking Sharpin develop a phenotype known as chronic proliferative dermatitis (CPDM), typified by progressive epidermal hyperplasia, apoptosis of keratinocytes, cutaneous and systemic eosinophilic inflammation, and hypoplasia of seconda...

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Detalhes bibliográficos
Main Authors: Potter, Christopher S., Wang, Zhe, Silva, Kathleen A., Kennedy, Victoria E., Stearns, Timothy M., Burzenski, Lisa, Shultz, Leonard D., HogenEsch, Harm, Sundberg, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897490/
https://ncbi.nlm.nih.gov/pubmed/24465642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085666
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